Synovo GmbH

Synovo's main pharmacology activities are based on assays and models for the selection of drug candidates with improved properties of Absorbtion, Disposition, Metabolism and Elimination (ADME or DMPK). Synovo establishes these parameters using human derived cells, proteins and systems wherever feasible to ensure the relevance of its data to use in man.

Synovo is engaged in projects in the fields of anti-inflammatory and immune suppressive drug optimisation on behalf of clients from the pharmaceutical industry. Synovo is also working in partnership with public sector laboratories to improve its systems and extend its technologies to protein and nucleic acid drugs.

The services are focused on:

Cell Engineering

As part of its pharmacology activities, Synovo has a cell biology team able to generate cell lines in support of assay design and screening projects. Team expertise centres on the construction of expression cassettes, expression of membrane proteins and the selection of high expressing cells. Cell line construction may be combined with fluorescent substrate design, assay design and electrophysiological characterisation of membrane proteins.

Pharmacology

Synovo offers a range of pharmacological support services that may form part of an integrated drug discovery project, or a stand-alone test. Our pharmacological expertise centres on inflammation and the general areas of pharmacokinetics and drug disposition with unlabelled materials. The ability to work without label allows us to cost effectively obtain distribution and metabolism data early in discovery. This information allows informed decision making on the fate of a compound prior to significant investment.

Because Synovo has in-house chemistry facilities, pharmacology can be coupled with compound formulation, galenics and stability studies if necessary. These packages are competitively priced to allow their use early in discovery.

Synthetic Chemistry

Synovo chemists have extensive medicinal chemistry experience, as well as custom synthesis. They also have experience in assay design and development with fluorescent substrates.

Synovo‘s chemistry services include:

• Synthesis of specific intermediates or screening compounds
• Method optimisation and scale-up
• Imobilisation of ligands
• ADME optimisation
• Preparation of fluorescent conjugates

As part of our synthetic chemistry offering, we provide custom glycoconjugate building blocks designed to meet the needs of our partners.  The products we offer include:

• a flexible system for carbohydrate labeling
• individually designed custom building blocks for saccharide synthesis
• neo-glycosides resistant to enzymatic degradation

Our chemistry team can support partners in both short term projects focusing on isolated chemistry problems or integrated projects over an extended period.

The team has a proven record of flexibility and delivery on projects with tight time scales. Synovo chemists have experience with most families of common drug compounds and labelling / conjugation chemistry.