Fraunhofer - Institute of Manufacturing Engineering and Automation
Institution / Head office:
Fraunhofer - Gesellschaft
Summary:
Development and buildup of customized technical and automation solutions for life science processes in laboratories and in production.
That, in a nutshell, is the key focus of the research and deveopment work carried out in the working field of "Bioproduction" at the Fraunhofer IPA
Description:
"Bioproduction" Technologies at the Fraunhofer IPA:
Technology Fields:
- Process Automation for laboratory automation
- Liquid Handling (Pico-, Nano- and Microliters), also of liquids with a high viscosity
- Cell Production
- Tissue Production
- High Throuput Sceening Devices
- Tools for Sample Prepatation and Handling
- Metrology
- Software for life science applications
Our Goals:
- higher reproducibility and quality in life science processes
- shorter development times for technical equipment
- miniaturized processes
- flexibilization of automated processes for adeption on real lab situation
- closed-loop process control for life science processes
Our recent technical highlights:
- idoT: Fast and direct nanodispense application for sampling of nanoliter droplets out of microwell plates (96, 384)
- Tissue Factory: Completly automated platform for production of two-layered human skin models as test systems
- Live Cell Monitoring: Automated cell culture platfom without a break of climatization in the culturing process
- m:Pal: Modular Process Automation Laboratory: A very flexible lab automation system
- ...
Research Themes:
Instrumentation for pharma and diagnostics
- systems for sample preparation (tissues and liquids)
- automated cell culture
- instrumentation for high throuput applications (point of care diagnostics, antibody assays, cell based assays)
- analysis systems (e.g. Nested-on-chip-PCR)
- production and functionalization of biofunctional surfaces
- production of DNA / proteine / peptide microarrays
Automated Cell Culture and automated Tissue Engineering
- equipment for automated cell culturing (human primery cells, cell lines, stem cells)
- automated tissue engineering (e.g. human skin models)
- automated cryo storage
- test systems and process metrology in compliance to GMP requirements
Solutions for bioprocess development
- upscaling of existing processes
- scaleable mini bio reactors
- online- and inline metrolgy for process control
Focused Applications
- drug discovery (HTS)
- cancer research
- regenerative medicine
- personalized medicine
- in-vitro and in-vivo diagnostics
Available equipment at Fraunhofer IPA:
Laboratories
- BioPoLiS: The BioProduction Laboratory in Stuttgart for corporate work of life science experts and engineers in one laboratory for shorter develpment times
- metrology laboratory for optical applications
- complete equiped modular operating room and laboratories for medical engineering
- laboratory for development of electronical devices
- test area for robot applications
- cleanroms
- laboratories for surface technologies
Our team
- mechanical engineers
- electrical engineers
- software engineers
- biologists
- physicists
- 25 scientists in total
Address:
Fraunhofer Institute for Manufacturing Engineering and Automation IPA
Nobelstrasse 12
70569 Stuttgart
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